User:Marvin O'Neal/OspA: Difference between revisions
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<h2>OspA & Lyme Disease</h2> | <h2>OspA & Lyme Disease</h2> | ||
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Acute Lyme Neuroborreliosis (LNB) is part of the second stage of Lyme disease in which the spirochete invades the peripheral and central nervous systems (CNS). Symptoms of LNB include: Bannwarth’s Syndrome, Lymphocytic Meningitis, and [http://www.rightdiagnosis.com/sym/cranial_neuritis.htm Cranial] and [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001619/ Peripheral Neuritis]. <span style="color:red">The presence of OspA in the cerebrospinal fluid (CSF) is responsible for this complex inflammatory response in the brain that leads to the neuroborreliosis.</span> The most frequent species of boreelia that is isolated from patients with Bannwarth's syndrome is <i>B.garini</i>. In the United States meningitis is the major symptom of Lyme Neuroborreliosis, and Bannwarth's syndrome is rarely seen.<SPAN STYLE="background:yellow"><b>cite me with rupprecht!!</b></span> | Acute Lyme Neuroborreliosis (LNB) is part of the second stage of Lyme disease in which the spirochete invades the peripheral and central nervous systems (CNS). Symptoms of LNB include: Bannwarth’s Syndrome, Lymphocytic Meningitis, and [http://www.rightdiagnosis.com/sym/cranial_neuritis.htm Cranial] and [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001619/ Peripheral Neuritis]. <span style="color:red">The presence of OspA in the cerebrospinal fluid (CSF) is responsible for this complex inflammatory response in the brain that leads to the neuroborreliosis.</span> The most frequent species of boreelia that is isolated from patients with Bannwarth's syndrome is <i>B.garini</i>. In the United States meningitis is the major symptom of Lyme Neuroborreliosis, and Bannwarth's syndrome is rarely seen.<SPAN STYLE="background:yellow"><b>cite me with rupprecht!!</b></span><ref name="rupprecht">PMID: 18097481</ref> | ||
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<h3>Other Speculations about OspA's role in Lyme Disease</h3> | <h3>Other Speculations about OspA's role in Lyme Disease</h3> | ||
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Borrelia have been shown to adhere to murine neural and glial cell lines using OspA. This adherence can be cytotoxic, due to OspA inducing apopotosis and astrogliosis.The borrelia spirochete is able to hide in certain areas of the body, specifically the extracellular matrix. This helps the spirochete survive by hiding from leukocytes circulating in the bloodstream. It is speculated that because OspA can also rapidly bind to plasminogen, and the plasminogen becomes activated plasmin that can degrade the extracellular matrix, borrelia could be using this to help invade the extracellular matrix. However there are also other possible explanations that do not involve OspA. Borrelia lead to local upregulation of the matrix metalloproteinase-9, which caues the digestion of the surrounding extracellular matrix.<SPAN STYLE="background:yellow"><b>cite me with rupprecht!!</b></span> | Borrelia have been shown to adhere to murine neural and glial cell lines using OspA. This adherence can be cytotoxic, due to OspA inducing apopotosis and astrogliosis.The borrelia spirochete is able to hide in certain areas of the body, specifically the extracellular matrix. This helps the spirochete survive by hiding from leukocytes circulating in the bloodstream. It is speculated that because OspA can also rapidly bind to plasminogen, and the plasminogen becomes activated plasmin that can degrade the extracellular matrix, borrelia could be using this to help invade the extracellular matrix. However there are also other possible explanations that do not involve OspA. Borrelia lead to local upregulation of the matrix metalloproteinase-9, which caues the digestion of the surrounding extracellular matrix.<SPAN STYLE="background:yellow"><b>cite me with rupprecht!!</b></span><ref name="rupprecht">PMID: 18097481</ref> | ||
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