Sandbox Reserved 452: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 5: | Line 5: | ||
== Structure == | == Structure == | ||
Secondary Structures | '''Secondary Structures''' | ||
The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper (bHLH-LZ) motif and an amino terminal transactivation domain<ref>PMID:8193530</ref>. The N-terminal domain functions in the activation of transcription, and the C-terminal, which contains the bHLH-LZ functions in in promoting the interaction between of c-myc and max. Immediatley following the basic region within the c-myc protein is the helix -loop-helix motif which has been shown to interact with DNA through binding <ref>PMID:8193530</ref>. C-myc by itself contains 1 alpha helices and 34 residues. Since c-myc is essentially inactive when it homodimerizes and has a very short half life, typically 20 to 20 minutes, it heterodimerizes with max to perform its biological functions. The c-myc gene is essientially found on human chromosome 8q24 and contains three exons. | The c-myc protein contains two specific regions that characterize them as transcription factors: a carboxy-terminal basix helix-loop-helix leucine zipper (bHLH-LZ) motif and an amino terminal transactivation domain<ref>PMID:8193530</ref>. The N-terminal domain functions in the activation of transcription, and the C-terminal, which contains the bHLH-LZ functions in in promoting the interaction between of c-myc and max. Immediatley following the basic region within the c-myc protein is the helix -loop-helix motif which has been shown to interact with DNA through binding <ref>PMID:8193530</ref>. C-myc by itself contains 1 alpha helices and 34 residues. Since c-myc is essentially inactive when it homodimerizes and has a very short half life, typically 20 to 20 minutes, it heterodimerizes with max to perform its biological functions. The c-myc gene is essientially found on human chromosome 8q24 and contains three exons. | ||
''Active Site''' | |||
<Structure load='1A93' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='1A93' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
