2fci: Difference between revisions
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{{STRUCTURE_2fci| PDB=2fci | SCENE= }} | {{STRUCTURE_2fci| PDB=2fci | SCENE= }} | ||
===Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase=== | ===Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase=== | ||
{{ABSTRACT_PUBMED_16410013}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PLCG1_BOVIN PLCG1_BOVIN]] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). | |||
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016410013</ref><references group="xtra"/> | <ref group="xtra">PMID:016410013</ref><references group="xtra"/><references/> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Phosphoinositide phospholipase C]] | [[Category: Phosphoinositide phospholipase C]] | ||
Revision as of 08:20, 23 April 2014
Structural basis for the requirement of two phosphotyrosines in signaling mediated by Syk tyrosine kinase
Template:ABSTRACT PUBMED 16410013
Function
[PLCG1_BOVIN] Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).
About this Structure
2fci is a 2 chain structure with sequence from Bos taurus. Full experimental information is available from OCA.
Reference
- Groesch TD, Zhou F, Mattila S, Geahlen RL, Post CB. Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase. J Mol Biol. 2006 Mar 10;356(5):1222-36. Epub 2005 Dec 27. PMID:16410013 doi:10.1016/j.jmb.2005.11.095
