1p57: Difference between revisions

Line 4:

==Overview==

Hepsin is an integral membrane protein that may participate in cell growth, and in maintaining proper cell morphology and is overexpressed in a number, of primary tumors. We have determined the 1.75 A resolution structure of, the extracellular component of human hepsin. This structure includes a, 255-residue trypsin-like serine protease domain and a 109-residue region, that forms a novel, poorly conserved, scavenger receptor cysteine-rich, (SRCR) domain. The two domains are associated with each other through a, single disulfide bond and an extensive network of noncovalent, interactions. The structure suggests how the extracellular region of, hepsin may be positioned with respect to the plasma membrane.

Hepsin is an integral membrane protein that may participate in cell growth and in maintaining proper cell morphology and is overexpressed in a number of primary tumors. We have determined the 1.75 A resolution structure of the extracellular component of human hepsin. This structure includes a 255-residue trypsin-like serine protease domain and a 109-residue region that forms a novel, poorly conserved, scavenger receptor cysteine-rich (SRCR) domain. The two domains are associated with each other through a single disulfide bond and an extensive network of noncovalent interactions. The structure suggests how the extracellular region of hepsin may be positioned with respect to the plasma membrane.

==About this Structure==

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[[Category: Protein complex]]

[[Category: Chan, H.]]

[[Category: Ho, J.D.]]

[[Category: Ho, J D.]]

[[Category: Katz, B.A.]]

[[Category: Katz, B A.]]

[[Category: Luong, C.]]

[[Category: McGrath, M.E.]]

[[Category: McGrath, M E.]]

[[Category: Mortara, K.]]

[[Category: Shrader, W.D.]]

[[Category: Shrader, W D.]]

[[Category: Somoza, J.R.]]

[[Category: Somoza, J R.]]

[[Category: Sperandio, D.]]

[[Category: Sprengeler, P.A.]]

[[Category: Sprengeler, P A.]]

[[Category: CR4]]

[[Category: scavenger receptor cysteine-rich domain]]

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[[Category: srcr]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Hepsin is an integral membrane protein that may participate in cell growth, and in maintaining proper cell morphology and is overexpressed in a number, of primary tumors. We have determined the 1.75 A resolution structure of, the extracellular component of human hepsin. This structure includes a, 255-residue trypsin-like serine protease domain and a 109-residue region, that forms a novel, poorly conserved, scavenger receptor cysteine-rich, (SRCR) domain. The two domains are associated with each other through a, single disulfide bond and an extensive network of noncovalent, interactions. The structure suggests how the extracellular region of, hepsin may be positioned with respect to the plasma membrane.
+Hepsin is an integral membrane protein that may participate in cell growth and in maintaining proper cell morphology and is overexpressed in a number of primary tumors. We have determined the 1.75 A resolution structure of the extracellular component of human hepsin. This structure includes a 255-residue trypsin-like serine protease domain and a 109-residue region that forms a novel, poorly conserved, scavenger receptor cysteine-rich (SRCR) domain. The two domains are associated with each other through a single disulfide bond and an extensive network of noncovalent interactions. The structure suggests how the extracellular region of hepsin may be positioned with respect to the plasma membrane.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Protein complex]]
 [[Category: Chan, H.]]
-[[Category: Ho, J.D.]]
+[[Category: Ho, J D.]]
-[[Category: Katz, B.A.]]
+[[Category: Katz, B A.]]
 [[Category: Luong, C.]]
-[[Category: McGrath, M.E.]]
+[[Category: McGrath, M E.]]
 [[Category: Mortara, K.]]
-[[Category: Shrader, W.D.]]
+[[Category: Shrader, W D.]]
-[[Category: Somoza, J.R.]]
+[[Category: Somoza, J R.]]
 [[Category: Sperandio, D.]]
-[[Category: Sprengeler, P.A.]]
+[[Category: Sprengeler, P A.]]
 [[Category: CR4]]
 [[Category: scavenger receptor cysteine-rich domain]]
@@ Line 28: / Line 28: @@
 [[Category: srcr]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:38:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:25:12 2008''