1p8v: Difference between revisions
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==Overview== | ==Overview== | ||
Direct interaction between platelet receptor glycoprotein Ibalpha | Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIbalpha-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs. | ||
==Disease== | ==Disease== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Dumas, J | [[Category: Dumas, J J.]] | ||
[[Category: Kumar, R.]] | [[Category: Kumar, R.]] | ||
[[Category: Mosyak, L.]] | [[Category: Mosyak, L.]] | ||
[[Category: Seehra, J.]] | [[Category: Seehra, J.]] | ||
[[Category: Somers, W | [[Category: Somers, W S.]] | ||
[[Category: DFP]] | [[Category: DFP]] | ||
[[Category: MES]] | [[Category: MES]] | ||
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[[Category: platelet glycoprotein receptor]] | [[Category: platelet glycoprotein receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:22 2008'' | ||
