4aqk: Difference between revisions
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{{STRUCTURE_4aqk| PDB=4aqk | SCENE= }} | {{STRUCTURE_4aqk| PDB=4aqk | SCENE= }} | ||
===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6=== | ===Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6=== | ||
{{ABSTRACT_PUBMED_22684075}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4aqk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AQK OCA]. | ||
[[Category: | |||
==Reference== | |||
<ref group="xtra">PMID:022684075</ref><references group="xtra"/><references/> | |||
[[Category: Arath]] | |||
[[Category: Inositol-pentakisphosphate 2-kinase]] | [[Category: Inositol-pentakisphosphate 2-kinase]] | ||
[[Category: Banos-Sanz, J I.]] | [[Category: Banos-Sanz, J I.]] | ||
Revision as of 09:02, 5 February 2014
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase in complex with ADP and IP6
Template:ABSTRACT PUBMED 22684075
Function
[IPPK_ARATH] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.[1] [2]
About this Structure
4aqk is a 1 chain structure with sequence from Arath. Full crystallographic information is available from OCA.
Reference
- Banos-Sanz JI, Sanz-Aparicio J, Brearley CA, Gonzalez B. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the apo form of InsP5 2-K from Arabidopsis thaliana. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jun 1;68(Pt 6):701-4. doi:, 10.1107/S1744309112017307. Epub 2012 May 23. PMID:22684075 doi:https://dx.doi.org/10.1107/S1744309112017307
- ↑ Stevenson-Paulik J, Bastidas RJ, Chiou ST, Frye RA, York JD. Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12612-7. Epub 2005 Aug 17. PMID:16107538 doi:10.1073/pnas.0504172102
- ↑ Sweetman D, Johnson S, Caddick SE, Hanke DE, Brearley CA. Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1). Biochem J. 2006 Feb 15;394(Pt 1):95-103. PMID:16223361 doi:BJ20051331
