Sandbox Reserved 468: Difference between revisions
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'''Linker region''' | '''Linker region''' | ||
In MMPs, the catalytic domain is followed by a domain consisting of 15–65 amino acid residues referred to as the <scene name='Sandbox_Reserved_468/Linker_region/3'>Linker Region</scene> or the hinge region. The length of this region varies between MMPs and does not have a well-determined structure. This region is typically rich in proline residues. Interestingly, the replacement of those with alanine drastically reduced the collagenolytic activity of certain MMPs, which may indicate that the presence of the correct linker structure is important for collagenolysis [4]. | In MMPs, the catalytic domain is followed by a domain consisting of 15–65 amino acid residues referred to as the <scene name='Sandbox_Reserved_468/Linker_region/3'>Linker Region</scene> or the hinge region. The length of this region varies between MMPs and does not have a well-determined structure. In MMP-1, the linker region is 16 residues long (242-258). This region is typically rich in proline residues. Interestingly, the replacement of those with alanine drastically reduced the collagenolytic activity of certain MMPs, which may indicate that the presence of the correct linker structure is important for collagenolysis [4]. | ||
Taken from a publication of the crystal structure [3]. | Taken from a publication of the crystal structure [3]. | ||
