1q1m: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Using an NMR-based fragment screening and X-ray crystal structure-based | Using an NMR-based fragment screening and X-ray crystal structure-based assembly, starting with millimolar ligands for both the catalytic site and the second phosphotyrosine binding site, we have identified a small-molecule inhibitor of protein tyrosine phosphatase 1B with low micromolar inhibition constant, high selectivity (30-fold) over the highly homologous T-cell protein tyrosine phosphatase, and good cellular activity in COS-7 cells. | ||
==Disease== | ==Disease== | ||
| Line 18: | Line 18: | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abad-Zapatero, C.]] | [[Category: Abad-Zapatero, C.]] | ||
[[Category: Ballaron, S | [[Category: Ballaron, S J.]] | ||
[[Category: Haasch, D | [[Category: Haasch, D L.]] | ||
[[Category: Hajduk, P | [[Category: Hajduk, P J.]] | ||
[[Category: Hutchins, C | [[Category: Hutchins, C W.]] | ||
[[Category: Jirousek, M | [[Category: Jirousek, M R.]] | ||
[[Category: Kaszubska, W.]] | [[Category: Kaszubska, W.]] | ||
[[Category: Liu, G.]] | [[Category: Liu, G.]] | ||
[[Category: Lubben, T | [[Category: Lubben, T H.]] | ||
[[Category: Pei, Z.]] | [[Category: Pei, Z.]] | ||
[[Category: Rondinone, C | [[Category: Rondinone, C M.]] | ||
[[Category: Trevillyan, J | [[Category: Trevillyan, J M.]] | ||
[[Category: Xin, Z.]] | [[Category: Xin, Z.]] | ||
[[Category: Zhao, H.]] | [[Category: Zhao, H.]] | ||
| Line 36: | Line 36: | ||
[[Category: ptp1b]] | [[Category: ptp1b]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:34:57 2008'' | ||
