Sandbox Reserved 485: Difference between revisions
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==Mechanism of Action== | ==Mechanism of Action== | ||
===Ran Cycle: Import and Export=== | ===Ran Cycle: Import and Export=== | ||
[[Image:Ran cycle.jpg | thumb|200px|]] | [[Image:Ran cycle.jpg | thumb|200px|cap=text|Ran Cycle through the Nuclear Pore Complex]] | ||
The Ran cycle plays a major function in translocating cargo such as RNA and proteins from and to the cytoplasm and nucleus. Cargo that is imported are typically proteins that are synthesized in the cytoplasm but function in the nucleus. A receptor protein known as an importin recognizes and binds to the nuclear localization signal, NLS, located on the cytoplasmic cargo. Importin-NLS protein complex is then able to be transported from the cytoplasm through the nuclear pore complex into the nucleus. Once inside the nucleus, the importin binds to Ran-GTP, allowing the release of the protein from the importin. The Ran-GTP-importin complex migrates back through the nuclear pore complex to release the importin back into the cytosplasm for reuse as Ran-GTP is hydrolyzed to Ran-GDP. | The Ran cycle plays a major function in translocating cargo such as RNA and proteins from and to the cytoplasm and nucleus. Cargo that is imported are typically proteins that are synthesized in the cytoplasm but function in the nucleus. A receptor protein known as an importin recognizes and binds to the nuclear localization signal, NLS, located on the cytoplasmic cargo. Importin-NLS protein complex is then able to be transported from the cytoplasm through the nuclear pore complex into the nucleus. Once inside the nucleus, the importin binds to Ran-GTP, allowing the release of the protein from the importin. The Ran-GTP-importin complex migrates back through the nuclear pore complex to release the importin back into the cytosplasm for reuse as Ran-GTP is hydrolyzed to Ran-GDP. | ||
