1q6k: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
The synthesis and biological activity of a series of aldehyde inhibitors | The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM. | ||
==Disease== | ==Disease== | ||
| Line 17: | Line 17: | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Catalano, J | [[Category: Catalano, J G.]] | ||
[[Category: Deaton, D | [[Category: Deaton, D N.]] | ||
[[Category: Furfine, E | [[Category: Furfine, E S.]] | ||
[[Category: Hassell, A | [[Category: Hassell, A M.]] | ||
[[Category: McFadyen, R | [[Category: McFadyen, R B.]] | ||
[[Category: Miller, A | [[Category: Miller, A B.]] | ||
[[Category: Miller, L | [[Category: Miller, L R.]] | ||
[[Category: Shewchuk, L | [[Category: Shewchuk, L M.]] | ||
[[Category: Willard, D | [[Category: Willard, D H.]] | ||
[[Category: Wright, L | [[Category: Wright, L L.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: TCO]] | [[Category: TCO]] | ||
| Line 32: | Line 32: | ||
[[Category: catk]] | [[Category: catk]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:36:23 2008'' | ||
