Sandbox Reserved 485: Difference between revisions
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==Possible Applications== | ==Possible Applications== | ||
It is obvious the importance Ran plays within the cell cycle. Defective Ran protein results in irregular reformation of the nuclear envelope, chromosome assembly and microtubule formation. Within the nucleus, malfunctions pertaining to factors associated with specific functions such as splicing and DNA replication These misregulations can result in immunodeficient disorders or X-linked | It is obvious the importance Ran plays within the cell cycle. Defective Ran protein results in irregular reformation of the nuclear envelope, chromosome assembly and microtubule formation. Within the nucleus, malfunctions pertaining to factors associated with specific functions such as splicing and DNA replication These misregulations can result in tissue damage in immunodeficient disorders such as Celiac's disease or X-linked neurodegenerative diseases such as Kennedy's disease. | ||
Further research is being conducted by Wisconsin Alumni Research Foundation(WARF) to design an inhibitor specific to Ran. Their research hopes to fully understand Ran’s mechanisms and regulatory measures in nuclear transport, mitotic spindle assembly and translational regulation. | |||
