Sandbox Reserved 474: Difference between revisions
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== Mechanism == | == Mechanism == | ||
Currently Unknown | Currently Unknown | ||
== Methods Used == | |||
Some of the methods used to determine the structure included: Crystallization, Data Collection and Processing, Obtaining the phases with molecular replacement and Model Building and refinement [3]. | |||
== Regulation of CRP expression == | == Regulation of CRP expression == | ||
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One other biological effect/function of CRP includes CRP's unique ability to identify pathogens to server as the hosts' first line of defense. | One other biological effect/function of CRP includes CRP's unique ability to identify pathogens to server as the hosts' first line of defense. | ||
== Mediator of Atherosclerosis == | |||
It has been shown that at known concentrations, CRP elicits effects which result in either proinflammatory or proatherosclerotic phenotype [4]. Several in vitro experiments have shown CRP to downregulate eNOS transcription, thus destabilizing its mRNA, resulting in in a decreased release of basel and stimulated NO, key endothelial factors [4]. By inhibiting NO production, CRP effectively facilitates apoptosis and blocks angiogenesis. Furthermore, it has been proposed that it is responsible for promoting the upregulation of nuclear factor-κB, which is a key promotor of several proatherosclerotic genes [4]. In addition, recent evidence has shown that it also has proatherogenic effects within smooth vascular muscle as well [1]. | |||
== References == | == References == | ||
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2. Steven Black, Irving Kushner, David Samols, C-reactive Protein*, Journal of Biological Chemistry, Volume 279,No. 47, Issue 19, 19 November 2004, Pages 48487-48490, DOI 10.1074/jbc.R400025200 | 2. Steven Black, Irving Kushner, David Samols, C-reactive Protein*, Journal of Biological Chemistry, Volume 279,No. 47, Issue 19, 19 November 2004, Pages 48487-48490, DOI 10.1074/jbc.R400025200 | ||
3. PDB of CRP | |||
4. Subodh Verma, Paul E. Szmitko, Edward T.H. Yeh, C-reactive Protein: Structure Affects Function, Journal of the American Heart Association, Volume 109, 2004, Pages 1914-1917, ISSN: 1524-4539, DOI: 10.1161/01.CIR.0000127085.32999.64 | |||
