1qzu: Difference between revisions

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==Overview==

Phosphopantothenoylcysteine (PPC) decarboxylase is an essential enzyme in, the biosynthesis of coenzyme A and catalyzes the decarboxylation of PPC to, phosphopantetheine. Human PPC decarboxylase has been expressed in, Escherichia coli, purified and crystallized. The Laue class of the, diffraction data appears to be 3m, suggesting space group R32 with two, monomers per asymmetric unit. However, the crystals belong to the space, group R3 and the asymmetric unit contains four monomers. The structure has, been solved using molecular replacement and refined to a current R factor, of 29%. The crystal packing can be considered as two interlaced lattices, each consistent with space group R32 and with the corresponding twofold, axes parallel to each other but separated along the threefold axis. Thus, the true space group is R3 with four monomers per asymmetric unit.

Phosphopantothenoylcysteine (PPC) decarboxylase is an essential enzyme in the biosynthesis of coenzyme A and catalyzes the decarboxylation of PPC to phosphopantetheine. Human PPC decarboxylase has been expressed in Escherichia coli, purified and crystallized. The Laue class of the diffraction data appears to be 3m, suggesting space group R32 with two monomers per asymmetric unit. However, the crystals belong to the space group R3 and the asymmetric unit contains four monomers. The structure has been solved using molecular replacement and refined to a current R factor of 29%. The crystal packing can be considered as two interlaced lattices, each consistent with space group R32 and with the corresponding twofold axes parallel to each other but separated along the threefold axis. Thus, the true space group is R3 with four monomers per asymmetric unit.

==About this Structure==

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[[Category: Phosphopantothenoylcysteine decarboxylase]]

[[Category: Single protein]]

[[Category: Ealick, S.E.]]

[[Category: Ealick, S E.]]

[[Category: Manoj, N.]]

[[Category: FMN]]

[[Category: alpha-beta sandwich]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Phosphopantothenoylcysteine (PPC) decarboxylase is an essential enzyme in, the biosynthesis of coenzyme A and catalyzes the decarboxylation of PPC to, phosphopantetheine. Human PPC decarboxylase has been expressed in, Escherichia coli, purified and crystallized. The Laue class of the, diffraction data appears to be 3m, suggesting space group R32 with two, monomers per asymmetric unit. However, the crystals belong to the space, group R3 and the asymmetric unit contains four monomers. The structure has, been solved using molecular replacement and refined to a current R factor, of 29%. The crystal packing can be considered as two interlaced lattices, each consistent with space group R32 and with the corresponding twofold, axes parallel to each other but separated along the threefold axis. Thus, the true space group is R3 with four monomers per asymmetric unit.
+Phosphopantothenoylcysteine (PPC) decarboxylase is an essential enzyme in the biosynthesis of coenzyme A and catalyzes the decarboxylation of PPC to phosphopantetheine. Human PPC decarboxylase has been expressed in Escherichia coli, purified and crystallized. The Laue class of the diffraction data appears to be 3m, suggesting space group R32 with two monomers per asymmetric unit. However, the crystals belong to the space group R3 and the asymmetric unit contains four monomers. The structure has been solved using molecular replacement and refined to a current R factor of 29%. The crystal packing can be considered as two interlaced lattices, each consistent with space group R32 and with the corresponding twofold axes parallel to each other but separated along the threefold axis. Thus, the true space group is R3 with four monomers per asymmetric unit.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Phosphopantothenoylcysteine decarboxylase]]
 [[Category: Single protein]]
-[[Category: Ealick, S.E.]]
+[[Category: Ealick, S E.]]
 [[Category: Manoj, N.]]
 [[Category: FMN]]
 [[Category: alpha-beta sandwich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:46:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:45:29 2008''