1r55: Difference between revisions
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==Overview== | ==Overview== | ||
Adam33 is a putative asthma susceptibility gene encoding for a | Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hammond, G.]] | [[Category: Hammond, G.]] | ||
[[Category: Le, H | [[Category: Le, H V.]] | ||
[[Category: Madison, V.]] | [[Category: Madison, V.]] | ||
[[Category: Mirza, U | [[Category: Mirza, U A.]] | ||
[[Category: Orth, P.]] | [[Category: Orth, P.]] | ||
[[Category: Prosise, W | [[Category: Prosise, W W.]] | ||
[[Category: Reichert, P.]] | [[Category: Reichert, P.]] | ||
[[Category: Strickland, C.]] | [[Category: Strickland, C.]] | ||
[[Category: Taremi, S | [[Category: Taremi, S S.]] | ||
[[Category: Wang, W.]] | [[Category: Wang, W.]] | ||
[[Category: Xiao, L.]] | [[Category: Xiao, L.]] | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:10 2008'' | ||
Revision as of 12:47, 21 February 2008
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Crystal structure of the catalytic domain of human ADAM 33
Overview
Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.
About this Structure
1R55 is a Single protein structure of sequence from Homo sapiens with ZN, CA, CL and 097 as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
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