1r5g: Difference between revisions

Line 4:

==Overview==

Substituted 3-amino-2-hydroxyamides and related hydroxyamides and, acylhydrazines were identified as inhibitors of human methionine, aminopeptidase-2 (MetAP2). Examination of substituents through parallel, synthesis and iterative structure-based design allowed the identification, of potent inhibitors with good selectivity against MetAP1. Diacylhydrazine, 3t (A-357300) was identified as an analogue displaying inhibition of, methionine processing and cellular proliferation in human microvascular, endothelial cells (HMVEC).

Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design allowed the identification of potent inhibitors with good selectivity against MetAP1. Diacylhydrazine 3t (A-357300) was identified as an analogue displaying inhibition of methionine processing and cellular proliferation in human microvascular endothelial cells (HMVEC).

==About this Structure==

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[[Category: Methionyl aminopeptidase]]

[[Category: Single protein]]

[[Category: BaMaung, N.Y.]]

[[Category: BaMaung, N Y.]]

[[Category: Craig, R.A.]]

[[Category: Craig, R A.]]

[[Category: Erickson, S.A.]]

[[Category: Erickson, S A.]]

[[Category: Henkin, J.]]

[[Category: Kawai, M.]]

[[Category: Kim, K.H.]]

[[Category: Kim, K H.]]

[[Category: Lesniewski, R.]]

[[Category: Lou, P.]]

Line 25:

[[Category: Park, C.]]

[[Category: Patel, J.]]

[[Category: Searle, X.B.]]

[[Category: Searle, X B.]]

[[Category: Sheppard, G.S.]]

[[Category: Sheppard, G S.]]

[[Category: Wang, J.]]

[[Category: Yang, F.]]

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[[Category: hydrolase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 16~~:47:03 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:17 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Substituted 3-amino-2-hydroxyamides and related hydroxyamides and, acylhydrazines were identified as inhibitors of human methionine, aminopeptidase-2 (MetAP2). Examination of substituents through parallel, synthesis and iterative structure-based design allowed the identification, of potent inhibitors with good selectivity against MetAP1. Diacylhydrazine, 3t (A-357300) was identified as an analogue displaying inhibition of, methionine processing and cellular proliferation in human microvascular, endothelial cells (HMVEC).
+Substituted 3-amino-2-hydroxyamides and related hydroxyamides and acylhydrazines were identified as inhibitors of human methionine aminopeptidase-2 (MetAP2). Examination of substituents through parallel synthesis and iterative structure-based design allowed the identification of potent inhibitors with good selectivity against MetAP1. Diacylhydrazine 3t (A-357300) was identified as an analogue displaying inhibition of methionine processing and cellular proliferation in human microvascular endothelial cells (HMVEC).
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Methionyl aminopeptidase]]
 [[Category: Single protein]]
-[[Category: BaMaung, N.Y.]]
+[[Category: BaMaung, N Y.]]
-[[Category: Craig, R.A.]]
+[[Category: Craig, R A.]]
-[[Category: Erickson, S.A.]]
+[[Category: Erickson, S A.]]
 [[Category: Henkin, J.]]
 [[Category: Kawai, M.]]
-[[Category: Kim, K.H.]]
+[[Category: Kim, K H.]]
 [[Category: Lesniewski, R.]]
 [[Category: Lou, P.]]
@@ Line 25: / Line 25: @@
 [[Category: Park, C.]]
 [[Category: Patel, J.]]
-[[Category: Searle, X.B.]]
+[[Category: Searle, X B.]]
-[[Category: Sheppard, G.S.]]
+[[Category: Sheppard, G S.]]
 [[Category: Wang, J.]]
 [[Category: Yang, F.]]
@@ Line 33: / Line 33: @@
 [[Category: hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:47:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:17 2008''