1rtb: Difference between revisions

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==Overview==

The crystal structure of ribonuclease A with bound thymidylic acid, tetramer is reported at 2.5-A resolution. The diffusion of the tetramer, into native orthorhombic crystals of the ribonuclease allows for the, formation of a structurally stable complex where the single-stranded, nucleic acid enters and leaves the enzyme's catalytic region in a, persistent 5'-3' direction. The binding of the tetramer to the enzyme's, surface is facilitated and mediated by electrostatic interactions between, basic protein residues and nucleotide phosphates. Two pyrimidine, nucleotides are bound to the enzyme's active site in a manner similar to, that observed for other complexes between ribonuclease A and nucleic acid, oligomers.

The crystal structure of ribonuclease A with bound thymidylic acid tetramer is reported at 2.5-A resolution. The diffusion of the tetramer into native orthorhombic crystals of the ribonuclease allows for the formation of a structurally stable complex where the single-stranded nucleic acid enters and leaves the enzyme's catalytic region in a persistent 5'-3' direction. The binding of the tetramer to the enzyme's surface is facilitated and mediated by electrostatic interactions between basic protein residues and nucleotide phosphates. Two pyrimidine nucleotides are bound to the enzyme's active site in a manner similar to that observed for other complexes between ribonuclease A and nucleic acid oligomers.

==About this Structure==

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[[Category: Pancreatic ribonuclease]]

[[Category: Single protein]]

[[Category: Birdsall, D.L.]]

[[Category: Birdsall, D L.]]

[[Category: McPherson, A.]]

[[Category: hydrolase(nucleic acid]]

[[Category: rna)]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:54:20 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The crystal structure of ribonuclease A with bound thymidylic acid, tetramer is reported at 2.5-A resolution. The diffusion of the tetramer, into native orthorhombic crystals of the ribonuclease allows for the, formation of a structurally stable complex where the single-stranded, nucleic acid enters and leaves the enzyme's catalytic region in a, persistent 5'-3' direction. The binding of the tetramer to the enzyme's, surface is facilitated and mediated by electrostatic interactions between, basic protein residues and nucleotide phosphates. Two pyrimidine, nucleotides are bound to the enzyme's active site in a manner similar to, that observed for other complexes between ribonuclease A and nucleic acid, oligomers.
+The crystal structure of ribonuclease A with bound thymidylic acid tetramer is reported at 2.5-A resolution. The diffusion of the tetramer into native orthorhombic crystals of the ribonuclease allows for the formation of a structurally stable complex where the single-stranded nucleic acid enters and leaves the enzyme's catalytic region in a persistent 5'-3' direction. The binding of the tetramer to the enzyme's surface is facilitated and mediated by electrostatic interactions between basic protein residues and nucleotide phosphates. Two pyrimidine nucleotides are bound to the enzyme's active site in a manner similar to that observed for other complexes between ribonuclease A and nucleic acid oligomers.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Pancreatic ribonuclease]]
 [[Category: Single protein]]
-[[Category: Birdsall, D.L.]]
+[[Category: Birdsall, D L.]]
 [[Category: McPherson, A.]]
 [[Category: hydrolase(nucleic acid]]
 [[Category: rna)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:49:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:54:20 2008''