1rwq: Difference between revisions

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==Overview==
==Overview==
The influence of aromatic substitution on a newly discovered class of, inhibitors of dipeptidyl peptidase IV was investigated. A 10(5)-fold, increase in potency was achieved by the optimization of aromatic, substituents in a parallel chemistry program. The observed SAR could be, explained by an X-ray structure of the protein-ligand complex.
The influence of aromatic substitution on a newly discovered class of inhibitors of dipeptidyl peptidase IV was investigated. A 10(5)-fold increase in potency was achieved by the optimization of aromatic substituents in a parallel chemistry program. The observed SAR could be explained by an X-ray structure of the protein-ligand complex.


==About this Structure==
==About this Structure==
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[[Category: exopeptidase]]
[[Category: exopeptidase]]


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