1sq2: Difference between revisions

Line 4:

==Overview==

Cartilaginous fish are the phylogenetically oldest living organisms known, to possess components of the vertebrate adaptive immune system. Key to, their immune response are heavy-chain, homodimeric immunoglobulins called, new antigen receptors (IgNARs), in which the variable (V) domains, recognize antigens with only a single immunoglobulin domain, akin to, camelid heavy-chain V domains. The 1.45 angstrom resolution crystal, structure of the type I IgNAR V domain in complex with hen egg-white, lysozyme (HEL) reveals a minimal antigen-binding domain that contains only, two of the three conventional complementarity-determining regions but, still binds HEL with nanomolar affinity by means of a binding interface, comparable in size to conventional antibodies.

Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.45 angstrom resolution crystal structure of the type I IgNAR V domain in complex with hen egg-white lysozyme (HEL) reveals a minimal antigen-binding domain that contains only two of the three conventional complementarity-determining regions but still binds HEL with nanomolar affinity by means of a binding interface comparable in size to conventional antibodies.

==About this Structure==

Line 16:

[[Category: Protein complex]]

[[Category: Dooley, H.]]

[[Category: Flajnik, M.F.]]

[[Category: Flajnik, M F.]]

[[Category: Stanfield, R.L.]]

[[Category: Stanfield, R L.]]

[[Category: Wilson, I.A.]]

[[Category: Wilson, I A.]]

[[Category: CL]]

[[Category: EDO]]

Line 24:

[[Category: protein-protein complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb 15 16:54:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:01 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-Cartilaginous fish are the phylogenetically oldest living organisms known, to possess components of the vertebrate adaptive immune system. Key to, their immune response are heavy-chain, homodimeric immunoglobulins called, new antigen receptors (IgNARs), in which the variable (V) domains, recognize antigens with only a single immunoglobulin domain, akin to, camelid heavy-chain V domains. The 1.45 angstrom resolution crystal, structure of the type I IgNAR V domain in complex with hen egg-white, lysozyme (HEL) reveals a minimal antigen-binding domain that contains only, two of the three conventional complementarity-determining regions but, still binds HEL with nanomolar affinity by means of a binding interface, comparable in size to conventional antibodies.
+Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.45 angstrom resolution crystal structure of the type I IgNAR V domain in complex with hen egg-white lysozyme (HEL) reveals a minimal antigen-binding domain that contains only two of the three conventional complementarity-determining regions but still binds HEL with nanomolar affinity by means of a binding interface comparable in size to conventional antibodies.
 ==About this Structure==
@@ Line 16: / Line 16: @@
 [[Category: Protein complex]]
 [[Category: Dooley, H.]]
-[[Category: Flajnik, M.F.]]
+[[Category: Flajnik, M F.]]
-[[Category: Stanfield, R.L.]]
+[[Category: Stanfield, R L.]]
-[[Category: Wilson, I.A.]]
+[[Category: Wilson, I A.]]
 [[Category: CL]]
 [[Category: EDO]]
@@ Line 24: / Line 24: @@
 [[Category: protein-protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:54:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:01 2008''