1sqa: Difference between revisions
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==Overview== | ==Overview== | ||
Several 8-substituted 2-naphthamidine-based inhibitors of the serine | Several 8-substituted 2-naphthamidine-based inhibitors of the serine protease urokinase plasminogen activator (uPA) are described. Direct attachment of five-membered saturated or unsaturated rings improved inhibitor performance; substitution with sulfones further improved binding profiles. Combination of these substituents or of previously described NH-linked heteroaromatic rings with 6-phenyl amide substituents provided further enhancements to potency and selectivity. | ||
==Disease== | ==Disease== | ||
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[[Category: U-plasminogen activator]] | [[Category: U-plasminogen activator]] | ||
[[Category: Geyer, A.]] | [[Category: Geyer, A.]] | ||
[[Category: Giranda, V | [[Category: Giranda, V L.]] | ||
[[Category: Klinghofer, V.]] | [[Category: Klinghofer, V.]] | ||
[[Category: McClellan, W | [[Category: McClellan, W J.]] | ||
[[Category: Nienaber, V.]] | [[Category: Nienaber, V.]] | ||
[[Category: Rockway, T | [[Category: Rockway, T W.]] | ||
[[Category: Stewart, K.]] | [[Category: Stewart, K.]] | ||
[[Category: Weitzberg, M.]] | [[Category: Weitzberg, M.]] | ||
[[Category: Wendt, M | [[Category: Wendt, M D.]] | ||
[[Category: Zhao, X.]] | [[Category: Zhao, X.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
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[[Category: serine protease]] | [[Category: serine protease]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:05 2008'' | ||
