1t1n: Difference between revisions

Line 4:

==Overview==

As new structural data have become available, somewhat contrasting, explanations of the Root effect in fish haemoglobins (Hb) have been, provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly, pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb, 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong, Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1, is presented. The structure is similar to that of Root effect fish Hbs, from Spot and T. bernacchii, suggesting that the differences in the pH, dependence cannot be related to the modulation of the R-state. In, comparison to T. bernacchii Hb 1, the role of the three mutations Thr41, (C6)alpha-->Ile, Ala97 (G3)alpha-->Ser and His41 (C7)beta-->Tyr at the, alpha1beta2-interface is discussed.

As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha-->Ile, Ala97 (G3)alpha-->Ser and His41 (C7)beta-->Tyr at the alpha1beta2-interface is discussed.

==About this Structure==

Line 23:

[[Category: oxygen transport]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb 15 16:54:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:08:56 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-As new structural data have become available, somewhat contrasting, explanations of the Root effect in fish haemoglobins (Hb) have been, provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly, pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb, 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong, Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1, is presented. The structure is similar to that of Root effect fish Hbs, from Spot and T. bernacchii, suggesting that the differences in the pH, dependence cannot be related to the modulation of the R-state. In, comparison to T. bernacchii Hb 1, the role of the three mutations Thr41, (C6)alpha--&gt;Ile, Ala97 (G3)alpha--&gt;Ser and His41 (C7)beta--&gt;Tyr at the, alpha1beta2-interface is discussed.
+As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha--&gt;Ile, Ala97 (G3)alpha--&gt;Ser and His41 (C7)beta--&gt;Tyr at the alpha1beta2-interface is discussed.
 ==About this Structure==
@@ Line 23: / Line 23: @@
 [[Category: oxygen transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:54:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:08:56 2008''