1ulb: Difference between revisions

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==Overview==

Competitive inhibitors of the salvage pathway enzyme purine-nucleoside, phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC, 2.4.2.1) have been designed by using the three-dimensional structure of, the enzyme as determined by x-ray crystallography. The process was an, iterative one that utilized interactive computer graphics, Monte, Carlo-based conformational searching, energy minimization, and x-ray, crystallography. The proposed compounds were synthesized and tested by an, in vitro assay. Among the compounds designed and synthesized are the most, potent competitive inhibitors of purine nucleoside phosphorylase thus far, reported.

Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one that utilized interactive computer graphics, Monte Carlo-based conformational searching, energy minimization, and x-ray crystallography. The proposed compounds were synthesized and tested by an in vitro assay. Among the compounds designed and synthesized are the most potent competitive inhibitors of purine nucleoside phosphorylase thus far reported.

==Disease==

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[[Category: Purine-nucleoside phosphorylase]]

[[Category: Single protein]]

[[Category: Babu, Y.S.]]

[[Category: Babu, Y S.]]

[[Category: Bugg, C.E.]]

[[Category: Bugg, C E.]]

[[Category: Carter, D.C.]]

[[Category: Carter, D C.]]

[[Category: Chen, S.F.]]

[[Category: Chen, S F.]]

[[Category: Cook, W.J.]]

[[Category: Cook, W J.]]

[[Category: Ealick, S.E.]]

[[Category: Ealick, S E.]]

[[Category: Greenhough, T.J.]]

[[Category: Greenhough, T J.]]

[[Category: Habash, J.]]

[[Category: Helliwell, J.R.]]

[[Category: Helliwell, J R.]]

[[Category: Parksjunior, R.E.]]

[[Category: Parksjunior, R E.]]

[[Category: Rule, S.A.]]

[[Category: Rule, S A.]]

[[Category: Stoeckler, J.D.]]

[[Category: Stoeckler, J D.]]

[[Category: GUN]]

[[Category: SO4]]

[[Category: pentosyltransferase]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Competitive inhibitors of the salvage pathway enzyme purine-nucleoside, phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC, 2.4.2.1) have been designed by using the three-dimensional structure of, the enzyme as determined by x-ray crystallography. The process was an, iterative one that utilized interactive computer graphics, Monte, Carlo-based conformational searching, energy minimization, and x-ray, crystallography. The proposed compounds were synthesized and tested by an, in vitro assay. Among the compounds designed and synthesized are the most, potent competitive inhibitors of purine nucleoside phosphorylase thus far, reported.
+Competitive inhibitors of the salvage pathway enzyme purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) have been designed by using the three-dimensional structure of the enzyme as determined by x-ray crystallography. The process was an iterative one that utilized interactive computer graphics, Monte Carlo-based conformational searching, energy minimization, and x-ray crystallography. The proposed compounds were synthesized and tested by an in vitro assay. Among the compounds designed and synthesized are the most potent competitive inhibitors of purine nucleoside phosphorylase thus far reported.
 ==Disease==
@@ Line 17: / Line 17: @@
 [[Category: Purine-nucleoside phosphorylase]]
 [[Category: Single protein]]
-[[Category: Babu, Y.S.]]
+[[Category: Babu, Y S.]]
-[[Category: Bugg, C.E.]]
+[[Category: Bugg, C E.]]
-[[Category: Carter, D.C.]]
+[[Category: Carter, D C.]]
-[[Category: Chen, S.F.]]
+[[Category: Chen, S F.]]
-[[Category: Cook, W.J.]]
+[[Category: Cook, W J.]]
-[[Category: Ealick, S.E.]]
+[[Category: Ealick, S E.]]
-[[Category: Greenhough, T.J.]]
+[[Category: Greenhough, T J.]]
 [[Category: Habash, J.]]
-[[Category: Helliwell, J.R.]]
+[[Category: Helliwell, J R.]]
-[[Category: Parksjunior, R.E.]]
+[[Category: Parksjunior, R E.]]
-[[Category: Rule, S.A.]]
+[[Category: Rule, S A.]]
-[[Category: Stoeckler, J.D.]]
+[[Category: Stoeckler, J D.]]
 [[Category: GUN]]
 [[Category: SO4]]
 [[Category: pentosyltransferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:03:05 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:25:43 2008''