3arn: Difference between revisions

Revision as of 10:19, 27 July 2012

3arn is a 3 chain structure of Deoxyuridine 5'-triphosphate nucleotidohydrolase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Miyahara S, Miyakoshi H, Yokogawa T, Chong KT, Taguchi J, Muto T, Endoh K, Yano W, Wakasa T, Ueno H, Takao Y, Fujioka A, Hashimoto A, Itou K, Yamamura K, Nomura M, Nagasawa H, Shuto S, Fukuoka M. Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors. J Med Chem. 2012 Apr 12;55(7):2970-80. Epub 2012 Mar 26. PMID:22339362 doi:10.1021/jm201628y

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 [[Image:3arn.png|left|200px]]
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 ===Human dUTPase in complex with novel uracil derivative===
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