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[[Image:4daw.png|left|200px]]
==Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex==
<StructureSection load='4daw' size='340' side='right' caption='[[4daw]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4daw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DAW FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0H2:[1,3-DIOXO-6-(PYRIDIN-2-YL-KAPPAN)-2,3-DIHYDRO-1H-ISOINDOL-5-YL-KAPPAC~5~][(THIOXOMETHYLIDENE)AZANIDO-KAPPAN](1,4,7-TRITHIONANE-KAPPA~3~S~1~,S~4~,S~7~)RUTHENIUM'>0H2</scene><br>
<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PAK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4daw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4daw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4daw RCSB], [http://www.ebi.ac.uk/pdbsum/4daw PDBsum]</span></td></tr>
<table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Better fit, less effort: An easy-to-synthesize ruthenium phthalimide complex (tan-colored carbon atoms in the picture) was designed to bind within the active site of the p21-activated kinase 1 in a novel fashion that differs from that of the previously established staurosporine-inspired metallopyridocarbazoles (gray-colored carbon atoms).


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The Art of Filling Protein Pockets Efficiently with Octahedral Metal Complexes.,Blanck S, Maksimoska J, Baumeister J, Harms K, Marmorstein R, Meggers E Angew Chem Int Ed Engl. 2012 Mar 1. doi: 10.1002/anie.201108865. PMID:22383326<ref>PMID:22383326</ref>
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{{STRUCTURE_4daw|  PDB=4daw  |  SCENE=  }}


===Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex===
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>


 
==See Also==
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*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
The line below this paragraph, {{ABSTRACT_PUBMED_22383326}}, adds the Publication Abstract to the page
== References ==
(as it appears on PubMed at http://www.pubmed.gov), where 22383326 is the PubMed ID number.
<references/>
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{{ABSTRACT_PUBMED_22383326}}
</StructureSection>
 
==About this Structure==
[[4daw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DAW OCA].
 
==Reference==
<ref group="xtra">PMID:022383326</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]

Revision as of 08:02, 5 June 2014

Crystal structure of PAK1 kinase domain with the ruthenium phthalimide complex

4daw, resolution 2.00Å

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