2lsi: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Solution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappa===

~~The entry 2lsi is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref> [[http://www.uniprot.org/uniprot/POLK_HUMAN POLK_HUMAN]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.<ref>PMID:10620008</ref> <ref>PMID:11024016</ref> <ref>PMID:12145297</ref> <ref>PMID:12444249</ref> <ref>PMID:12952891</ref> <ref>PMID:14630940</ref> <ref>PMID:15533436</ref>

~~Authors~~: ~~Liu, D~~.~~, Ryu, K~~.~~, Ko, J~~.~~, Choi, B~~.

==About this Structure==

[[2lsi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSI OCA].

~~Description~~: ~~Solution structure of~~ polymerase-interacting domain ~~of human~~ Rev1 ~~in complex with translesional synthesis polymerase kappa~~

==Reference==

[[Category: DNA-directed DNA polymerase]]

[[Category: Homo sapiens]]

[[Category: Choi, B.]]

[[Category: Ko, J.]]

[[Category: Liu, D.]]

[[Category: Ryu, K.]]

[[Category: Polymerase kappa]]

[[Category: Polymerase-interacting domain]]

[[Category: Rev1]]

[[Category: Rev1-interacting motif]]

[[Category: Transferase]]

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-'''Unreleased structure'''
+{{STRUCTURE_2lsi|  PDB=2lsi  |  SCENE=  }}
+===Solution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappa===
-The entry 2lsi is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/REV1_HUMAN REV1_HUMAN]] Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.<ref>PMID:10536157</ref> <ref>PMID:10760286</ref> <ref>PMID:11278384</ref> <ref>PMID:11485998</ref> <ref>PMID:22266823</ref>  [[http://www.uniprot.org/uniprot/POLK_HUMAN POLK_HUMAN]] DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity.<ref>PMID:10620008</ref> <ref>PMID:11024016</ref> <ref>PMID:12145297</ref> <ref>PMID:12444249</ref> <ref>PMID:12952891</ref> <ref>PMID:14630940</ref> <ref>PMID:15533436</ref>
-Authors: Liu, D., Ryu, K., Ko, J., Choi, B.
+==About this Structure==
+[[2lsi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSI OCA].
-Description: Solution structure of polymerase-interacting domain of human Rev1 in complex with translesional synthesis polymerase kappa
+==Reference==
+<references group="xtra"/><references/>
+[[Category: DNA-directed DNA polymerase]]
+[[Category: Homo sapiens]]
+[[Category: Choi, B.]]
+[[Category: Ko, J.]]
+[[Category: Liu, D.]]
+[[Category: Ryu, K.]]
+[[Category: Polymerase kappa]]
+[[Category: Polymerase-interacting domain]]
+[[Category: Rev1]]
+[[Category: Rev1-interacting motif]]
+[[Category: Transferase]]