1zml: Difference between revisions
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==Overview== | ==Overview== | ||
A series of functionalized aryl boronic acids were synthesized and | A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa. | ||
==Disease== | ==Disease== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Babine, R | [[Category: Babine, R E.]] | ||
[[Category: Bibbins, F.]] | [[Category: Bibbins, F.]] | ||
[[Category: Gorga, J | [[Category: Gorga, J C.]] | ||
[[Category: Jin, L.]] | [[Category: Jin, L.]] | ||
[[Category: Lazarova, T | [[Category: Lazarova, T I.]] | ||
[[Category: Meyers, H | [[Category: Meyers, H V.]] | ||
[[Category: Rynkiewicz, M | [[Category: Rynkiewicz, M J.]] | ||
[[Category: Strickler, J | [[Category: Strickler, J E.]] | ||
[[Category: 412]] | [[Category: 412]] | ||
[[Category: BCT]] | [[Category: BCT]] | ||
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[[Category: inhibitor]] | [[Category: inhibitor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:02 2008'' | ||
