2a3d: Difference between revisions

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==Overview==

Although de novo protein design is an important endeavor with implications, for understanding protein folding, until now, structures have been, determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle, protein, alpha3D, is reported. The structure of alpha3D was not based on, any natural protein, and yet it shows thermodynamic and spectroscopic, properties typical of native proteins. A variety of features contribute to, its unique structure, including electrostatics, the packing of a diverse, set of hydrophobic side chains, and a loop that incorporates common, capping motifs. Thus, it is now possible to design a complex protein with, a well defined and predictable three-dimensional structure.

Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle protein, alpha3D, is reported. The structure of alpha3D was not based on any natural protein, and yet it shows thermodynamic and spectroscopic properties typical of native proteins. A variety of features contribute to its unique structure, including electrostatics, the packing of a diverse set of hydrophobic side chains, and a loop that incorporates common capping motifs. Thus, it is now possible to design a complex protein with a well defined and predictable three-dimensional structure.

==About this Structure==

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[[Category: Escherichia coli]]

[[Category: Protein complex]]

[[Category: Bryson, J.W.]]

[[Category: Bryson, J W.]]

[[Category: Cheng, H.]]

[[Category: Degrado, W.F.]]

[[Category: Degrado, W F.]]

[[Category: Roder, H.]]

[[Category: Walsh, S.T.R.]]

[[Category: Walsh, S T.R.]]

[[Category: three-helix bundle]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:12 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Although de novo protein design is an important endeavor with implications, for understanding protein folding, until now, structures have been, determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle, protein, alpha3D, is reported. The structure of alpha3D was not based on, any natural protein, and yet it shows thermodynamic and spectroscopic, properties typical of native proteins. A variety of features contribute to, its unique structure, including electrostatics, the packing of a diverse, set of hydrophobic side chains, and a loop that incorporates common, capping motifs. Thus, it is now possible to design a complex protein with, a well defined and predictable three-dimensional structure.
+Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle protein, alpha3D, is reported. The structure of alpha3D was not based on any natural protein, and yet it shows thermodynamic and spectroscopic properties typical of native proteins. A variety of features contribute to its unique structure, including electrostatics, the packing of a diverse set of hydrophobic side chains, and a loop that incorporates common capping motifs. Thus, it is now possible to design a complex protein with a well defined and predictable three-dimensional structure.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Escherichia coli]]
 [[Category: Protein complex]]
-[[Category: Bryson, J.W.]]
+[[Category: Bryson, J W.]]
 [[Category: Cheng, H.]]
-[[Category: Degrado, W.F.]]
+[[Category: Degrado, W F.]]
 [[Category: Roder, H.]]
-[[Category: Walsh, S.T.R.]]
+[[Category: Walsh, S T.R.]]
 [[Category: three-helix bundle]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:13:57 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:23:12 2008''