3b8r: Difference between revisions

Revision as of 21:41, 25 July 2012

3b8r is a 2 chain structure of Vascular Endothelial Growth Factor Receptor with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Weiss MM, Harmange JC, Polverino AJ, Bauer D, Berry L, Berry V, Borg G, Bready J, Chen D, Choquette D, Coxon A, Demelfi T, Doerr N, Estrada J, Flynn J, Graceffa RF, Harriman SP, Kaufman S, La DS, Long A, Neervannan S, Patel VF, Potashman M, Regal K, Roveto PM, Schrag ML, Starnes C, Tasker A, Teffera Y, Whittington DA, Zanon R. Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors. J Med Chem. 2008 Mar 27;51(6):1668-80. Epub 2008 Mar 7. PMID:18324759 doi:10.1021/jm701098w

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 [[Image:3b8r.png|left|200px]]
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 ===Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor===
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