Gag polyprotein: Difference between revisions
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[[Image:1gwp.png|left|200px|thumb|The mature CA<sup>N</sup> domain of the [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) HIV-1] Gag<sup>283</sup> polyprotein ([[1gwp]]), is a protein involved in formation of the capsid core particle. The structure of the CA<sup>N</sup> domain was determined through [[NMR]] by Tang et al. <ref name="source">PMID:12032547</ref>.]] | [[Image:1gwp.png|left|200px|thumb|The mature CA<sup>N</sup> domain of the [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_12) HIV-1] Gag<sup>283</sup> polyprotein ([[1gwp]]), is a protein involved in formation of the capsid core particle. The structure of the CA<sup>N</sup> domain was determined through [[NMR]] by Tang et al. <ref name="source">PMID:12032547</ref>.]] | ||
{{STRUCTURE_1gwp| PDB=1gwp | SCENE= }} | {{STRUCTURE_1gwp| PDB=1gwp | SCENE= }} | ||
{{STRUCTURE_2xde| PDB=2xde | SIZE=400| SCENE= |right|CAPTION=Galactose oxidase with Cu+2 and Na+ ions, [[2xde] }} | |||
The '''Gag polyprotein''' (Gag) is part of the basic infrastructure of retroviruses. The Gag is processed during maturation of matrix protein, capsid protein, spacer peptide and nucleocapsid protein. For detailed discussion of HIV-1 Gag polyprotein see [[Hiv-1 gag]]. | The '''Gag polyprotein''' (Gag) is part of the basic infrastructure of retroviruses. The Gag is processed during maturation of matrix protein, capsid protein, spacer peptide and nucleocapsid protein. For detailed discussion of HIV-1 Gag polyprotein see [[Hiv-1 gag]]. | ||
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[[1esk]] - Gag residues 12-53 – NMR<BR /> | [[1esk]] - Gag residues 12-53 – NMR<BR /> | ||
[[1baj]] – Gag C terminal<BR /> | [[1baj]] – Gag C terminal<BR /> | ||
[[2znf]] – Gag zinc fingerlike domain | [[2znf]] – Gag zinc fingerlike domain - NMR<BR /> | ||
[[2h3q]], [[2h3v]], [[2h3z]] - Gag residues 2-132 + phosphatidyl inositol bisphosphate - NMR<BR /> | [[2h3q]], [[2h3v]], [[2h3z]] - Gag residues 2-132 + phosphatidyl inositol bisphosphate - NMR<BR /> | ||
[[1mt7]], [[1mt8]] – Gag MA-CA cleavage site + protease retropepsin (mutant) <BR /> | [[1mt7]], [[1mt8]] – Gag MA-CA cleavage site + protease retropepsin (mutant) <BR /> | ||
