2bid: Difference between revisions

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==Overview==

We report the solution structure of BID, an intracellular cross-talk agent, that can amplify FAS/TNF apoptotic signal through the mitochondria death, pathway after Caspase 8 cleavage. BID contains eight alpha helices where, two central hydrophobic helices are surrounded by six amphipathic ones., The fold resembles poreforming bacterial toxins and shows similarity to, BCL-XL although sequence homology to BCL-XL is limited to the 16-residue, BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by, aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex., Additionally, we show that the overall structure of BID is preserved after, cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent, and -independent modes of action in inducing mitochondrial damage.

We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage. BID contains eight alpha helices where two central hydrophobic helices are surrounded by six amphipathic ones. The fold resembles poreforming bacterial toxins and shows similarity to BCL-XL although sequence homology to BCL-XL is limited to the 16-residue BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex. Additionally, we show that the overall structure of BID is preserved after cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent and -independent modes of action in inducing mitochondrial damage.

==About this Structure==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Chou, J.J.]]

[[Category: Chou, J J.]]

[[Category: Li, H.]]

[[Category: Salvesen, G.S.]]

[[Category: Salvesen, G S.]]

[[Category: Wagner, G.]]

[[Category: Yuan, J.]]

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[[Category: programmed cell death]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:10 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-We report the solution structure of BID, an intracellular cross-talk agent, that can amplify FAS/TNF apoptotic signal through the mitochondria death, pathway after Caspase 8 cleavage. BID contains eight alpha helices where, two central hydrophobic helices are surrounded by six amphipathic ones., The fold resembles poreforming bacterial toxins and shows similarity to, BCL-XL although sequence homology to BCL-XL is limited to the 16-residue, BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by, aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex., Additionally, we show that the overall structure of BID is preserved after, cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent, and -independent modes of action in inducing mitochondrial damage.
+We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage. BID contains eight alpha helices where two central hydrophobic helices are surrounded by six amphipathic ones. The fold resembles poreforming bacterial toxins and shows similarity to BCL-XL although sequence homology to BCL-XL is limited to the 16-residue BH3 domain. Furthermore, we modeled a complex of BCL-XL and BID by aligning the BID and BAK BH3 motifs in the known BCL-XL-BAK BH3 complex. Additionally, we show that the overall structure of BID is preserved after cleavage by Caspase 8. We propose that BID has both BH3 domain-dependent and -independent modes of action in inducing mitochondrial damage.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Chou, J.J.]]
+[[Category: Chou, J J.]]
 [[Category: Li, H.]]
-[[Category: Salvesen, G.S.]]
+[[Category: Salvesen, G S.]]
 [[Category: Wagner, G.]]
 [[Category: Yuan, J.]]
@@ Line 21: / Line 21: @@
 [[Category: programmed cell death]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:16:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:38:10 2008''