1dgp: Difference between revisions

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[[Image:1dgp.png|left|200px]]
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{{STRUCTURE_1dgp|  PDB=1dgp  |  SCENE=  }}  
{{STRUCTURE_1dgp|  PDB=1dgp  |  SCENE=  }}  
===ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX===
===ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX===
{{ABSTRACT_PUBMED_10825154}}


 
==Function==
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[[http://www.uniprot.org/uniprot/ARIS_PENRO ARIS_PENRO]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce aristolochene. Aristolochene is the likely parent compound for a number of sesquiterpenoid toxins produced by filamentous fungi.<ref>PMID:8440737</ref> <ref>PMID:15186158</ref>
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{{ABSTRACT_PUBMED_10825154}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:010825154</ref><references group="xtra"/>
<ref group="xtra">PMID:010825154</ref><references group="xtra"/><references/>
[[Category: Aristolochene synthase]]
[[Category: Aristolochene synthase]]
[[Category: Penicillium roqueforti]]
[[Category: Penicillium roqueforti]]

Revision as of 06:43, 10 April 2014

Template:STRUCTURE 1dgp

ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX

Template:ABSTRACT PUBMED 10825154

Function

[ARIS_PENRO] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic sesquiterpene aristolochene. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce aristolochene. Aristolochene is the likely parent compound for a number of sesquiterpenoid toxins produced by filamentous fungi.[1] [2]

About this Structure

1dgp is a 2 chain structure with sequence from Penicillium roqueforti. Full crystallographic information is available from OCA.

Reference

  1. Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW. Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti. J Biol Chem. 2000 Aug 18;275(33):25533-9. PMID:10825154 doi:10.1074/jbc.M000433200
  1. ↑ Proctor RH, Hohn TM. Aristolochene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti. J Biol Chem. 1993 Feb 25;268(6):4543-8. PMID:8440737
  2. ↑ Felicetti B, Cane DE. Aristolochene synthase: mechanistic analysis of active site residues by site-directed mutagenesis. J Am Chem Soc. 2004 Jun 16;126(23):7212-21. PMID:15186158 doi:10.1021/ja0499593

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