3s57: Difference between revisions

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~~[[Image:3s57.jpg|left|200px]]~~

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===ABH2 cross-linked with undamaged dsDNA-1 containing cofactors===

==Function==

[[http://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>

==About this Structure==

[[3s57]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S57 OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Chen, B.]]

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-[[Image:3s57.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3s57", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3s57|  PDB=3s57  |  SCENE=  }}
 ===ABH2 cross-linked with undamaged dsDNA-1 containing cofactors===
+{{ABSTRACT_PUBMED_22659876}}
+==Function==
+[[http://www.uniprot.org/uniprot/ALKB2_HUMAN ALKB2_HUMAN]] Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.<ref>PMID:12486230</ref> <ref>PMID:12594517</ref> <ref>PMID:16174769</ref> <ref>PMID:18519673</ref> <ref>PMID:18432238</ref>
 ==About this Structure==
 [[3s57]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S57 OCA].
+==Reference==
+<ref group="xtra">PMID:022659876</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Chen, B.]]