4aub: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4aub| PDB=4aub | SCENE= }} | {{STRUCTURE_4aub| PDB=4aub | SCENE= }} | ||
===the complex Structure of the bacterial aldo-keto reductase AKR14A1 with NADP and citrate=== | ===the complex Structure of the bacterial aldo-keto reductase AKR14A1 with NADP and citrate=== | ||
{{ABSTRACT_PUBMED_23103600}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GPR_ECOLI GPR_ECOLI]] Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.<ref>PMID:12583903</ref> <ref>PMID:16077126</ref> <ref>PMID:18620424</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4aub]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[4aub]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AUB OCA]. | ||
[[Category: | |||
==Reference== | |||
<ref group="xtra">PMID:023103600</ref><references group="xtra"/><references/> | |||
[[Category: Ecoli]] | |||
[[Category: Ellis, E M.]] | [[Category: Ellis, E M.]] | ||
[[Category: Lapthorn, A.]] | [[Category: Lapthorn, A.]] | ||
[[Category: Zhu, X.]] | [[Category: Zhu, X.]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 13:36, 12 March 2014
the complex Structure of the bacterial aldo-keto reductase AKR14A1 with NADP and citrate
Template:ABSTRACT PUBMED 23103600
Function
[GPR_ECOLI] Catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). The physiological role of gpr is the detoxification of L-GAP, which may be formed by non-enzymatic racemization of GAP. Also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.[1] [2] [3]
About this Structure
4aub is a 8 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.
Reference
- Lapthorn AJ, Zhu X, Ellis EM. The diversity of microbial aldo/keto reductases from Escherichia coli K12. Chem Biol Interact. 2013 Feb 25;202(1-3):168-77. doi: 10.1016/j.cbi.2012.10.008. , Epub 2012 Oct 24. PMID:23103600 doi:https://dx.doi.org/10.1016/j.cbi.2012.10.008
- ↑ Grant AW, Steel G, Waugh H, Ellis EM. A novel aldo-keto reductase from Escherichia coli can increase resistance to methylglyoxal toxicity. FEMS Microbiol Lett. 2003 Jan 21;218(1):93-9. PMID:12583903
- ↑ Ko J, Kim I, Yoo S, Min B, Kim K, Park C. Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases. J Bacteriol. 2005 Aug;187(16):5782-9. PMID:16077126 doi:https://dx.doi.org/10.1128/JB.187.16.5782-5789.2005
- ↑ Desai KK, Miller BG. A metabolic bypass of the triosephosphate isomerase reaction. Biochemistry. 2008 Aug 5;47(31):7983-5. doi: 10.1021/bi801054v. Epub 2008 Jul 12. PMID:18620424 doi:https://dx.doi.org/10.1021/bi801054v
