4f3v: Difference between revisions

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[[Image:4f3v.jpg|left|200px]]
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{{STRUCTURE_4f3v|  PDB=4f3v  |  SCENE=  }}  
{{STRUCTURE_4f3v|  PDB=4f3v  |  SCENE=  }}  
===Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis===
===Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis===
{{ABSTRACT_PUBMED_23818233}}


==Function==
[[http://www.uniprot.org/uniprot/ECCA1_MYCTU ECCA1_MYCTU]] Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Shows ATPase activity. Could provide energy for export of ESX-1 substrates.<ref>PMID:18974091</ref> <ref>PMID:16368961</ref> 


==About this Structure==
==About this Structure==
[[4f3v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3V OCA].  
[[4f3v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F3V OCA].  
==Reference==
<ref group="xtra">PMID:023818233</ref><references group="xtra"/><references/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Evans, T J.]]
[[Category: Evans, T J.]]

Revision as of 14:19, 10 July 2013

Template:STRUCTURE 4f3v

Crystal structure of N-terminal domain of EccA1 ATPase from ESX-1 secretion system of Mycobacterium tuberculosis

Template:ABSTRACT PUBMED 23818233

Function

[ECCA1_MYCTU] Probably part of a complex that is involved in secretion of ESX-1 substrates, such as EsxA (ESAT-6) and EsxB (CFP-10). Shows ATPase activity. Could provide energy for export of ESX-1 substrates.[1] [2]

About this Structure

4f3v is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  1. Wagner JM, Evans TJ, Korotkov KV. Crystal structure of the N-terminal domain of EccA ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis. Proteins. 2013 Jul 2. doi: 10.1002/prot.24351. PMID:23818233 doi:10.1002/prot.24351
  1. ↑ Luthra A, Mahmood A, Arora A, Ramachandran R. Characterization of Rv3868, an essential hypothetical protein of the ESX-1 secretion system in Mycobacterium tuberculosis. J Biol Chem. 2008 Dec 26;283(52):36532-41. doi: 10.1074/jbc.M807144200. Epub 2008, Oct 30. PMID:18974091 doi:10.1074/jbc.M807144200
  2. ↑ Brodin P, Majlessi L, Marsollier L, de Jonge MI, Bottai D, Demangel C, Hinds J, Neyrolles O, Butcher PD, Leclerc C, Cole ST, Brosch R. Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence. Infect Immun. 2006 Jan;74(1):88-98. PMID:16368961 doi:10.1128/IAI.74.1.88-98.2006

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