2duv: Difference between revisions
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==Overview== | ==Overview== | ||
A novel series of 3-hydroxychromones were prepared and found to be CDK | A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells. | ||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
3-Hydroxychromones as cyclin-dependent kinase inhibitors: | 3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation., Lee J, Park T, Jeong S, Kim KH, Hong C, Bioorg Med Chem Lett. 2007 Mar 1;17(5):1284-7. Epub 2006 Dec 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17178224 17178224] | ||
[[Category: Cyclin-dependent kinase]] | [[Category: Cyclin-dependent kinase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
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[[Category: Hong, C.]] | [[Category: Hong, C.]] | ||
[[Category: Jeong, S.]] | [[Category: Jeong, S.]] | ||
[[Category: Kim, K | [[Category: Kim, K H.]] | ||
[[Category: Lee, J.]] | [[Category: Lee, J.]] | ||
[[Category: Park, T.]] | [[Category: Park, T.]] | ||
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[[Category: serine/threonine-protein kinase]] | [[Category: serine/threonine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:02:56 2008'' | ||
