PE/PPE Protein Complex: Difference between revisions
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New page: <StructureSection load="2g38" size="400" color="" frame="true" spin="on" Scene='2g38/Pe_ppe_longitudinal/1' align="right" caption= > left|200px<br /> ===A PE/PPE ... |
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The heterodimeric <scene name='2g38/Pe_ppe_longitudinal/1'>PE/PPE protein complex</scene> from ''M. tuberculosis'' is composed of a 99 amino acid <scene name='2g38/Pe_ppe_pe/3'>PE protein</scene> protein (Rv2431c, shown in RED) and a 194 amino acid <scene name='2g38/Pe_ppe_ppe/1'>PPE protein</scene> (Rv2430c, shown in BLUE), that are encoded next to each other on the M. tuberculosis genome (suggestive of a potential operon). These proteins represent two of the largest protein families in the M. tuberculosis genome. The PE and PPE proteins form an <scene name='2g38/Pe_ppe_longitudinal/1'>elongated helical structure</scene>, reminiscent of a four-helix bundle, which can be best viewed down the <scene name='2g38/Pe_ppe_axis/2'>axis</scene>. The protein interaction <scene name='2g38/Pe_ppe_interface/1'>interface</scene> between the two proteins is lined with hydrophobic residues, contributing to the stability of the protein complex. Click here to view a <scene name='2g38/Pe_ppe_space_fill/2'>SpaceFill</scene> representation. | The heterodimeric <scene name='2g38/Pe_ppe_longitudinal/1'>PE/PPE protein complex</scene> from ''M. tuberculosis'' is composed of a 99 amino acid <scene name='2g38/Pe_ppe_pe/3'>PE protein</scene> protein (Rv2431c, shown in RED) and a 194 amino acid <scene name='2g38/Pe_ppe_ppe/1'>PPE protein</scene> (Rv2430c, shown in BLUE), that are encoded next to each other on the M. tuberculosis genome (suggestive of a potential operon). These proteins represent two of the largest protein families in the M. tuberculosis genome. The PE and PPE proteins form an <scene name='2g38/Pe_ppe_longitudinal/1'>elongated helical structure</scene>, reminiscent of a four-helix bundle, which can be best viewed down the <scene name='2g38/Pe_ppe_axis/2'>axis</scene>. The protein interaction <scene name='2g38/Pe_ppe_interface/1'>interface</scene> between the two proteins is lined with hydrophobic residues, contributing to the stability of the protein complex. Click here to view a <scene name='2g38/Pe_ppe_space_fill/2'>SpaceFill</scene> representation. | ||
{{ABSTRACT_PUBMED_16690741}} | {{ABSTRACT_PUBMED_16690741}} | ||
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[[Category: Tb structural genomics consortium]] | [[Category: Tb structural genomics consortium]] | ||
[[Category: Tbsgc]] | [[Category: Tbsgc]] | ||
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Created with the participation of [[User:Michael Strong|Michael Strong]], [[User:Eran Hodis|Eran Hodis]]. | Created with the participation of [[User:Michael Strong|Michael Strong]], [[User:Eran Hodis|Eran Hodis]]. | ||
