2oxu: Difference between revisions

Revision as of 15:52, 10 June 2012

Ligands:

CA, ZN

Gene:

MMP12, HME (Homo sapiens)

Activity:

Macrophage elastase, with EC number 3.4.24.65

Related:

1y93, 1rmz, 2oxw, 2oxz, 2oy2, 2oy4

Structural annotation:
Resources:	InterPro : Ipr000585, Ipr006025, Ipr002477, Ipr001818, Ipr006026 Pfam : PF00413 UniProt : P39900

Functional annotation:
Cellular component:	proteinaceous extracellular matrix
Biological process:	metabolic process proteolysis cell motility
Molecular function:	metallopeptidase activity catalytic activity metal ion binding macrophage elastase activity peptidase activity hydrolase activity metalloendopeptidase activity calcium ion binding zinc ion binding

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

2oxu is a 1 chain structure of Elastase and Matrix metalloproteinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Bertini I, Calderone V, Fragai M, Luchinat C, Maletta M, Yeo KJ. Snapshots of the reaction mechanism of matrix metalloproteinases. Angew Chem Int Ed Engl. 2006 Dec 4;45(47):7952-5. PMID:17096442 doi:10.1002/anie.200603100

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