2ja5: Difference between revisions
New page: left|200px<br /> <applet load="2ja5" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ja5, resolution 3.8Å" /> '''CPD LESION CONTAININ... |
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==About this Structure== | ==About this Structure== | ||
2JA5 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with MG and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JA5 OCA]]. | 2JA5 is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]] with MG and ZN as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferase Transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JA5 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 08:28:18 2007'' | ||
Revision as of 06:23, 30 October 2007
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CPD LESION CONTAINING RNA POLYMERASE II ELONGATION COMPLEX A
Overview
Cells use transcription-coupled repair (TCR) to efficiently eliminate DNA, lesions such as ultraviolet light-induced cyclobutane pyrimidine dimers, (CPDs). Here we present the structure-based mechanism for the first step, in eukaryotic TCR, CPD-induced stalling of RNA polymerase (Pol) II. A CPD, in the transcribed strand slowly passes a translocation barrier and enters, the polymerase active site. The CPD 5'-thymine then directs uridine, misincorporation into messenger RNA, which blocks translocation., Artificial replacement of the uridine by adenosine enables CPD bypass;, thus, Pol II stalling requires CPD-directed misincorporation. In the, stalled complex, the lesion is inaccessible, and the polymerase, conformation is unchanged. This is consistent with nonallosteric, recruitment of ... [(full description)]
About this Structure
2JA5 is a [Protein complex] structure of sequences from [Saccharomyces cerevisiae] with MG and ZN as [ligands]. Active as [Transferase], with EC number [2.7.7.6]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
CPD damage recognition by transcribing RNA polymerase II., Brueckner F, Hennecke U, Carell T, Cramer P, Science. 2007 Feb 9;315(5813):859-62. PMID:17290000
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Protein complex
- Saccharomyces cerevisiae
- Brueckner, F.
- Carell, T.
- Cramer, P.
- Hennecke, U.
- MG
- ZN
- Arrest
- Cpd
- Cyclobutane pyrimidine dimer
- Damage recognition
- Dna damage
- Dna lesion
- Dna-binding
- Dna-directed rna polymerase
- Elongation complex
- Lesion recognition
- Metal-binding
- Misincorporation
- Nuclear protein
- Nucleotidyltransferase
- Phosphorylation
- Photolesion
- Rna polymerase ii
- Stalling
- Tcr
- Thymine dimer
- Transcription
- Transcription bubble
- Transcription- coupled repair
- Transferase
- Transferase/dna/rna
- Zinc
- Zinc-finger
