Corticosteroid-binding globulin: Difference between revisions
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''Lyon'' | ''Lyon'' | ||
CBG Lyon has an exon 5 point mutation which changes Aspartate 367 to an asparagine. This mutation lies close to the cortisol-binding pocket and reduces cortisol affinity by four-fold. Heterozygotes show reduction in immunoreactive CBG levels and total cortisol levels but were otherwise healthy, while homozygotes presented with fatigue, depressed mood and low blood pressure. | CBG Lyon has an exon 5 point mutation which changes <scene name='Corticosteroid-binding_globulin/Asp367/1'>Aspartate 367</scene>to an asparagine. This mutation lies close to the cortisol-binding pocket and reduces cortisol affinity by four-fold. Heterozygotes show reduction in immunoreactive CBG levels and total cortisol levels but were otherwise healthy, while homozygotes presented with fatigue, depressed mood and low blood pressure. | ||
''CBG Null'' | ''CBG Null'' | ||
