Allosteric modulation of H-Ras GTPase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: {{STRUCTURE_3k8y| PDB=3k8y | SCENE= }} '''H-Ras''' is a small monomeric GTPase protein that is found inside of cells. It helps regulate cell division in cells through signal transdu... |
No edit summary |
||
| Line 2: | Line 2: | ||
'''H-Ras''' is a small monomeric GTPase protein that is found inside of cells. It helps regulate cell division in cells through signal transduction pathways such as the Ras pathway. H-Ras is also known as a molecular switch, it contains two switch regions: Switch I and Switch II. Switch I is a Thymine 35 and switch II is a Glycine 60, both of these switches depend on the phosphate group on a GTP molecule to turn “on” and “off”. In the Ras catalytic cycle, Ras is activated when it attaches to a GTP molecule turning both switch regions “on”. This pathway also involves GTPase activating protein, which hydrolyzes the GTP attached to the Ras causing the switches to turn “off”. | '''H-Ras''' is a small monomeric GTPase protein that is found inside of cells. It helps regulate cell division in cells through signal transduction pathways such as the Ras pathway. H-Ras is also known as a molecular switch, it contains two switch regions: Switch I and Switch II. Switch I is a Thymine 35 and switch II is a Glycine 60, both of these switches depend on the phosphate group on a GTP molecule to turn “on” and “off”. In the Ras catalytic cycle, Ras is activated when it attaches to a GTP molecule turning both switch regions “on”. This pathway also involves GTPase activating protein, which hydrolyzes the GTP attached to the Ras causing the switches to turn “off”. | ||
===Mutations=== | |||
Mutation is Q61 causes shift in amino acids | |||
[[Image:RasCacliumacetate.jpg|thumb|center|Calcium Acetate/Loop 7/Helix 3/GppNHp]] | |||
<!-- | <!-- | ||
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page. | ||
