Allosteric modulation of H-Ras GTPase: Difference between revisions
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== Mutations == | == Mutations == | ||
[[Image:Q61Ras.jpg|400px|left]] Mutation | [[Image:Q61Ras.jpg|400px|left]] The residue Glutamine-61 (Q61) plays a large role in the mutation of the Ras protein. When the Q61 becomes mutated in stops the GTPase of the Ras causing the protein to continuously stay active. Mutated Q61 is found in many cancer patients. | ||
Mutation of Q61 causes a shift in Loop 7 and Helix 3 causing the conformation of the amino acids and switch regions to change. | |||
== Reference == | |||
<ref group="xtra">PMID:20194776</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Buhrman, G.]] | |||
[[Category: Holzapfel, G.]] | |||
[[Category: Mattos, C.]] | |||
[[Category: Acetylation]] | |||
[[Category: Cell membrane]] | |||
[[Category: Disease mutation]] | |||
[[Category: Golgi apparatus]] | |||
[[Category: Gtp-binding]] | |||
[[Category: Lipoprotein]] | |||
[[Category: Membrane]] | |||
[[Category: Methylation]] | |||
[[Category: Nucleotide-binding]] | |||
[[Category: Oncoprotein]] | |||
[[Category: Palmitate]] | |||
[[Category: Prenylation]] | |||
[[Category: Protein-nucleotide complex]] | |||
[[Category: Proto-oncogene]] | |||
[[Category: S-nitrosylation]] | |||
