2ht6: Difference between revisions

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==Overview==

Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique, sequence features. We report here the crystallographic structure, determination of the Gem G-domain in complex with nucleotide to 2.4 A, resolution. Although the basic Ras protein fold is maintained, the Gem, switch regions emphatically differ from the Ras paradigm. Our ensuing, biochemical characterization indicates that Gem G-domain markedly prefers, GDP over GTP. Two known functions of Gem are distinctly affected by, spatially separated clusters of mutations.

Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique sequence features. We report here the crystallographic structure determination of the Gem G-domain in complex with nucleotide to 2.4 A resolution. Although the basic Ras protein fold is maintained, the Gem switch regions emphatically differ from the Ras paradigm. Our ensuing biochemical characterization indicates that Gem G-domain markedly prefers GDP over GTP. Two known functions of Gem are distinctly affected by spatially separated clusters of mutations.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Hirsch, J.A.]]

[[Category: Hirsch, J A.]]

[[Category: Opatowsky, Y.]]

[[Category: GDP]]

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[[Category: small g-protein]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:26 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique, sequence features. We report here the crystallographic structure, determination of the Gem G-domain in complex with nucleotide to 2.4 A, resolution. Although the basic Ras protein fold is maintained, the Gem, switch regions emphatically differ from the Ras paradigm. Our ensuing, biochemical characterization indicates that Gem G-domain markedly prefers, GDP over GTP. Two known functions of Gem are distinctly affected by, spatially separated clusters of mutations.
+Gem, a member of the Rad,Gem/Kir subfamily of small G-proteins, has unique sequence features. We report here the crystallographic structure determination of the Gem G-domain in complex with nucleotide to 2.4 A resolution. Although the basic Ras protein fold is maintained, the Gem switch regions emphatically differ from the Ras paradigm. Our ensuing biochemical characterization indicates that Gem G-domain markedly prefers GDP over GTP. Two known functions of Gem are distinctly affected by spatially separated clusters of mutations.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Hirsch, J.A.]]
+[[Category: Hirsch, J A.]]
 [[Category: Opatowsky, Y.]]
 [[Category: GDP]]
@@ Line 22: / Line 22: @@
 [[Category: small g-protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:33:25 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:26 2008''