2hth: Difference between revisions

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==Overview==

The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into, vesicles that accumulate within multivesicular bodies (MVBs)., Crystallographic and biochemical analyses reveal that the GLUE domain of, the human ESCRT-II EAP45 (also called VPS36) subunit is a split, pleckstrin-homology domain that binds ubiquitin along one edge of the, beta-sandwich. The structure suggests how human ESCRT-II can couple, recognition of ubiquitinated cargoes and endosomal phospholipids during, MVB protein sorting.

The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.

==Disease==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Alam, S.L.]]

[[Category: Alam, S L.]]

[[Category: Hill, C.P.]]

[[Category: Hill, C P.]]

[[Category: Sundquist, W.I.]]

[[Category: Sundquist, W I.]]

[[Category: Whitby, F.G.]]

[[Category: Whitby, F G.]]

[[Category: glue domain]]

[[Category: ph domain]]

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[[Category: viral budding]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:35 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into, vesicles that accumulate within multivesicular bodies (MVBs)., Crystallographic and biochemical analyses reveal that the GLUE domain of, the human ESCRT-II EAP45 (also called VPS36) subunit is a split, pleckstrin-homology domain that binds ubiquitin along one edge of the, beta-sandwich. The structure suggests how human ESCRT-II can couple, recognition of ubiquitinated cargoes and endosomal phospholipids during, MVB protein sorting.
+The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Alam, S.L.]]
+[[Category: Alam, S L.]]
-[[Category: Hill, C.P.]]
+[[Category: Hill, C P.]]
-[[Category: Sundquist, W.I.]]
+[[Category: Sundquist, W I.]]
-[[Category: Whitby, F.G.]]
+[[Category: Whitby, F G.]]
 [[Category: glue domain]]
 [[Category: ph domain]]
@@ Line 26: / Line 26: @@
 [[Category: viral budding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:33:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:45:35 2008''