2kxq: Difference between revisions
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{{STRUCTURE_2kxq| PDB=2kxq | SCENE= }} | {{STRUCTURE_2kxq| PDB=2kxq | SCENE= }} | ||
===Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide=== | ===Solution Structure of Smurf2 WW2 and WW3 bound to Smad7 PY motif containing peptide=== | ||
{{ABSTRACT_PUBMED_20937913}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SMUF2_HUMAN SMUF2_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.<ref>PMID:11389444</ref><ref>PMID:12717440</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:020937913</ref><references group="xtra"/> | <ref group="xtra">PMID:020937913</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chong, A.]] | [[Category: Chong, A.]] | ||
