3tvj: Difference between revisions
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{{STRUCTURE_3tvj| PDB=3tvj | SCENE= }} | {{STRUCTURE_3tvj| PDB=3tvj | SCENE= }} | ||
===Catalytic fragment of MASP-2 in complex with its specific inhibitor developed by directed evolution on SGCI scaffold=== | |||
{{ABSTRACT_PUBMED_22511776}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Defects in MASP2 are the cause of MASP2 deficiency (MASPD) [MIM:[http://omim.org/entry/613791 613791]]. MASPD is a disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.<ref>PMID:12904520</ref><ref>PMID:17252003</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MASP2_HUMAN MASP2_HUMAN]] Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.<ref>PMID:10946292</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022511776</ref><references group="xtra"/> | <ref group="xtra">PMID:022511776</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mannan-binding lectin-associated serine protease-2]] | [[Category: Mannan-binding lectin-associated serine protease-2]] | ||
