2seb: Difference between revisions

Line 4:

==Overview==

Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC, class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the, peptide-binding site appears to be critical in discriminating DR molecules, linked to increased disease susceptibility. We have determined the 2.5 A, x-ray structure of the DR4 molecule with the strongest linkage to RA, (DRB1*0401) complexed with a human collagen II peptide. Details of a, predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4, peptide position suggest how it may participate in both antigen binding, and TCR activation. A model is proposed for the DR4 recognition of, collagen II (261-273), an antigen immunodominant in human-transgenic mouse, models of RA.

Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the peptide-binding site appears to be critical in discriminating DR molecules linked to increased disease susceptibility. We have determined the 2.5 A x-ray structure of the DR4 molecule with the strongest linkage to RA (DRB1*0401) complexed with a human collagen II peptide. Details of a predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4 peptide position suggest how it may participate in both antigen binding and TCR activation. A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA.

==Disease==

Line 19:

[[Category: Cupo, S.]]

[[Category: Dessen, A.]]

[[Category: Lawrence, C.M.]]

[[Category: Lawrence, C M.]]

[[Category: Wiley, D.C.]]

[[Category: Wiley, D C.]]

[[Category: Zaller, D.M.]]

[[Category: Zaller, D M.]]

[[Category: NAG]]

[[Category: complex (mhc class ii/superantigen)]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 17~~:42:10 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:49:04 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC, class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the, peptide-binding site appears to be critical in discriminating DR molecules, linked to increased disease susceptibility. We have determined the 2.5 A, x-ray structure of the DR4 molecule with the strongest linkage to RA, (DRB1*0401) complexed with a human collagen II peptide. Details of a, predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4, peptide position suggest how it may participate in both antigen binding, and TCR activation. A model is proposed for the DR4 recognition of, collagen II (261-273), an antigen immunodominant in human-transgenic mouse, models of RA.
+Genetic predisposition to rheumatoid arthritis (RA) is linked to the MHC class II allele HLA-DR4. The charge of the amino acid at DRbeta71 in the peptide-binding site appears to be critical in discriminating DR molecules linked to increased disease susceptibility. We have determined the 2.5 A x-ray structure of the DR4 molecule with the strongest linkage to RA (DRB1*0401) complexed with a human collagen II peptide. Details of a predicted salt bridge between lysine DRbeta71 and aspartic acid at the P4 peptide position suggest how it may participate in both antigen binding and TCR activation. A model is proposed for the DR4 recognition of collagen II (261-273), an antigen immunodominant in human-transgenic mouse models of RA.
 ==Disease==
@@ Line 19: / Line 19: @@
 [[Category: Cupo, S.]]
 [[Category: Dessen, A.]]
-[[Category: Lawrence, C.M.]]
+[[Category: Lawrence, C M.]]
-[[Category: Wiley, D.C.]]
+[[Category: Wiley, D C.]]
-[[Category: Zaller, D.M.]]
+[[Category: Zaller, D M.]]
 [[Category: NAG]]
 [[Category: complex (mhc class ii/superantigen)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:42:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:49:04 2008''