2tgf: Difference between revisions

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==Overview==

The solution structure of transforming growth factor alpha has been, determined by a combination of high-resolution 1H-nuclear magnetic, resonance and distance geometry and restrained molecular dynamics. The 382, restraints derived from the NMR experiments were used to calculate many, distance geometry structures, which were then refined by restrained, molecular mechanics. Five of these structures were further refined using a, variety of methods. Comparison of independently measured parameters, such, as calculated hydrogen bonding patterns and experimental amide exchange, rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational, interconversion observed are suggested. Finally comparisons between this, work and others on this topic have been made.

The solution structure of transforming growth factor alpha has been determined by a combination of high-resolution 1H-nuclear magnetic resonance and distance geometry and restrained molecular dynamics. The 382 restraints derived from the NMR experiments were used to calculate many distance geometry structures, which were then refined by restrained molecular mechanics. Five of these structures were further refined using a variety of methods. Comparison of independently measured parameters, such as calculated hydrogen bonding patterns and experimental amide exchange rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational interconversion observed are suggested. Finally comparisons between this work and others on this topic have been made.

==About this Structure==

Line 13:

[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Campbell, I.D.]]

[[Category: Campbell, I D.]]

[[Category: Cooke, R.M.]]

[[Category: Cooke, R M.]]

[[Category: Harvey, T.S.]]

[[Category: Harvey, T S.]]

[[Category: Tappin, M.J.]]

[[Category: Tappin, M J.]]

[[Category: Wilkinson, A.J.]]

[[Category: Wilkinson, A J.]]

[[Category: growth factor]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The solution structure of transforming growth factor alpha has been, determined by a combination of high-resolution 1H-nuclear magnetic, resonance and distance geometry and restrained molecular dynamics. The 382, restraints derived from the NMR experiments were used to calculate many, distance geometry structures, which were then refined by restrained, molecular mechanics. Five of these structures were further refined using a, variety of methods. Comparison of independently measured parameters, such, as calculated hydrogen bonding patterns and experimental amide exchange, rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational, interconversion observed are suggested. Finally comparisons between this, work and others on this topic have been made.
+The solution structure of transforming growth factor alpha has been determined by a combination of high-resolution 1H-nuclear magnetic resonance and distance geometry and restrained molecular dynamics. The 382 restraints derived from the NMR experiments were used to calculate many distance geometry structures, which were then refined by restrained molecular mechanics. Five of these structures were further refined using a variety of methods. Comparison of independently measured parameters, such as calculated hydrogen bonding patterns and experimental amide exchange rates, have been used to evaluate the accuracy of the structures. Also, possible mechanisms to explain the pH-dependent conformational interconversion observed are suggested. Finally comparisons between this work and others on this topic have been made.
 ==About this Structure==
@@ Line 13: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Campbell, I.D.]]
+[[Category: Campbell, I D.]]
-[[Category: Cooke, R.M.]]
+[[Category: Cooke, R M.]]
-[[Category: Harvey, T.S.]]
+[[Category: Harvey, T S.]]
-[[Category: Tappin, M.J.]]
+[[Category: Tappin, M J.]]
-[[Category: Wilkinson, A.J.]]
+[[Category: Wilkinson, A J.]]
 [[Category: growth factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:42:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:49:41 2008''