Spectrin: Difference between revisions
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[[Image:3lbx.png|left|200px|thumb|Crystal Structure of Spectrin [[3lbx]]]] | [[Image:3lbx.png|left|200px|thumb|Crystal Structure of Spectrin [[3lbx]]]] | ||
{{STRUCTURE_3lbx| PDB=3lbx | SIZE=300| SCENE= | {{STRUCTURE_3lbx| PDB=3lbx | SIZE=300| SCENE= |right|CAPTION=Spectrin [[3lbx]] }} | ||
[[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of alpha1 and beta1 monomers. In invertebrates there are SPT alpha, beta and betaH. In vertebrates there are SPT alpha1 (SPTA1), alpha2 (SPTA2) and beta1 (SPTB1) to beta5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. The images at the left and at the right correspond to one representative Spectrin, ''i.e.'' the crystal structure of human Spectrin ([[3lbx]]). | [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of alpha1 and beta1 monomers. In invertebrates there are SPT alpha, beta and betaH. In vertebrates there are SPT alpha1 (SPTA1), alpha2 (SPTA2) and beta1 (SPTB1) to beta5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. The images at the left and at the right correspond to one representative Spectrin, ''i.e.'' the crystal structure of human Spectrin ([[3lbx]]). | ||
