User:Eran Hodis: Difference between revisions
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Welcome to Proteopedia. | Welcome to Proteopedia. | ||
<applet load="1eve" size="450" color="white" frame="true" align="right" spinBox="true" script="1eve/E2020_in_ache/6" caption="1eve, resolution 2.50Å" /> | |||
The X-ray structure of the E2020-''Tc''AChE complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/6'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad, or the 'oxyanion hole', but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>. | |||
You're encouraged to take a look around. Use the toolbar on the left to either search for a specific page, or click "Random page" to view a random page. | You're encouraged to take a look around. Use the toolbar on the left to either search for a specific page, or click "Random page" to view a random page. | ||
