User:Eran Hodis: Difference between revisions

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<big>Welcome to Proteopedia</big>

===Green links change the 3D ~~structures~~!===

===Green links change the 3D image!===

The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds [[acetylcholinesterase]] (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/6'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>.

The anti-Alzheimer's drug E2020 (marketed as Aricept®) is an inhibitor that binds [[acetylcholinesterase]] (AChE) with high affinity. The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/7'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>.

User:Eran Hodis: Difference between revisions

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@@ Line 2: / Line 2: @@
 <big>Welcome to Proteopedia</big>
-===Green links change the 3D structures!===
+===Green links change the 3D image!===
-The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds [[acetylcholinesterase]] (AChE) with high affinity.  The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/6'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>.
+The anti-Alzheimer's drug E2020 (marketed as Aricept&reg;) is an inhibitor that binds [[acetylcholinesterase]] (AChE) with high affinity.  The X-ray structure of the E2020-AChE (AChE from ''Torpedo california'') complex shows that E2020 has a <scene name='1eve/E2020_close_up_with_84_279/7'>unique orientation</scene> along the active-site gorge, extending from the anionic subsite (<scene name='1eve/E2020_close_up_with_84lbld/3'>W84</scene>) of the active site, at the bottom, to the peripheral anionic site (<scene name='1eve/E2020_close_up_with_84_279lbld/2'>near W279</scene>), at the top, via aromatic stacking interactions with conserved aromatic acid residues. E2020 does not, however, interact directly with either the catalytic triad or the 'oxyanion hole' but only <scene name='1eve/E20_interactionshown/3'>indirectly via solvent molecules</scene>.