P53-DNA Recognition: Difference between revisions
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===DNA Backbone Contact=== | ===DNA Backbone Contact=== | ||
Another arginine residue, <scene name='Sandbox_Reserved_170/Arg273/2'>Arg273, contacts the phosphodiester backbone</scene> and seems to be important for p53-DNA binding. Moreover, Arg273 is the second most common missense mutation in human cancer (Figure 2). | Another arginine residue, <scene name='Sandbox_Reserved_170/Arg273/2'>Arg273, contacts the phosphodiester backbone</scene> and seems to be important for human p53-DNA binding. Moreover, Arg273 is the second most common missense mutation in human cancer (Figure 2). | ||
[[Image:Kitayner-etal-Figure7.jpg|thumb|right|400px|Figure 7: DNA shape readout of narrow minor groove regions with enhanced electrostatic potential by Arg248<ref name='kitayner'/>. Nature Publishing Group has provided permission for usage of this figure.]] | [[Image:Kitayner-etal-Figure7.jpg|thumb|right|400px|Figure 7: DNA shape readout of narrow minor groove regions with enhanced electrostatic potential by Arg248<ref name='kitayner'/>. Nature Publishing Group has provided permission for usage of this figure.]] | ||
